Scientific Studies
Mitochondrial Function
[1.] Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38.
[2.] NAD+ and sirtuins in aging and disease. Imai SI, Guarente L. Trends Cell Biol. 2014 Apr 28. pii: S0962-8924(14)00063-4.
[3.] NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease. Cerutti R, Pirinen E, Lamperti C, Marchet S, Sauve AA, Li W, Leoni V, Schon EA, Dantzer F, Auwerx J, Viscomi C, Zeviani M. Cell Metab. 2014 May 7. pii: S1550-4131(14)00164-8. *
[4.] Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3. Khan NA, Auranen M, Paetau I, Pirinen E, Euro L, Forsström S, Pasila L, Velagapudi V, Carroll CJ, Auwerx J, Suomalainen A. EMBO Mol Med. 2014 Apr 6.
[5.] The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. Cell Metab. 2012 Jun 6;15(6):838-47. *
Cognitive Function
[1.] Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models. Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Sauve AA, Pasinetti GM. Neurobiol Aging. 2013 Jun;34(6):1581-8. *
Neuropathies
[1.] Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. Sasaki Y, Araki T, Milbrandt J. J Neurosci. 2006 Aug 16;26(33):8484-91.
Myopathies
[1.] NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy. Goody MF, Kelly MW, Reynolds CJ, Khalil A, Crawford BD, Henry CA. PLoS Biol. 2012;10(10):e1001409
Metabolism
[1.] Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Yoshino J, Mills KF, Yoon MJ, Imai S. Cell Metab. 2011 Oct 5;14(4):528-36.
NAD+ Biosynthesis
[1.] Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae. Lu SP, Kato M, Lin SJ. J Biol Chem. 2009 Jun 19;284(25):17110-9.
[2.] Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism. Belenky P, Christensen KC, Gazzaniga F, Pletnev AA, Brenner C. J Biol Chem. 2009 Jan 2;284(1):158-64.
[3.] Nicotinamide riboside kinase structures reveal new pathways to NAD+. Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C. PLoS Biol. 2007 Oct 2;5(10):e263.
[3.] Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Cell. 2007 May 4;129(3):473-84.
[4.] Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Bieganowski P, Brenner C. Cell. 2004 May 14;117(4):495-502.
[5.] The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J. Cell. 2013 Jul 18;154(2):430-41.
[6.] NAD+ as a signaling molecule modulating metabolism. Cantó C, Auwerx J. Cold Spring Harb Symp Quant Biol. 2011;76:291-8.
[7.] NAD⁺ metabolism: a therapeutic target for age-related metabolic disease.Mouchiroud L, Houtkooper RH, Auwerx J. Crit Rev Biochem Mol Biol. 2013 Jul-Aug;48(4):397-408.
Reviews
[1.] NAD+ and sirtuins in aging and disease. Imai SI, Guarente L. Trends Cell Biol. 2014 Apr 28. pii: S0962-8924(14)00063-4
[2.] Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Chi Y, Sauve AA. Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):657-61
[3.] Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Bogan KL, Brenner C. Annu Rev Nutr. 2008;28:115-30.
[4.] NAD+ and vitamin B3: from metabolism to therapies. Sauve AA. J Pharmacol Exp Ther. 2008 Mar;324(3):883-93.
[5.] NAD+ metabolism in health and disease. Belenky P, Bogan KL, Brenner C. Trends Biochem Sci. 2007 Jan;32(1):12-9. Epub 2006 Dec 11
via Live Cell Research.