With RbAp48, we were able to reverse age-related memory loss in the mice,” said Columbia’s Dr Eric Kandel, who shared the 2000 Nobel Prize in medicine for discoveries of the molecular basis of memory and led the research. “The researchers plan to see what social and dietary factors might boost RbAp48 in mice, said Kandel, who will be 84 in November. Pharmaceuticals, nutraceuticals, physical and cognitive exercise are all candidates, said Columbia’s Dr Scott Small, co-senior author of the study.